Document 0480
 DOCN  M9480480
 TI    Rochalimaea antibodies in HIV-associated neurologic disease.
 DT    9410
 AU    Schwartzman WA; Patnaik M; Barka NE; Peter JB; Section of Infectious
       Diseases, UCLA Department of Medicine.
 SO    Neurology. 1994 Jul;44(7):1312-6. Unique Identifier : AIDSLINE
       MED/94309818
 AB    Rochalimaea henselae, a recently described pathogen thought to cause
       syndromes as varied as bacillary angiomatosis, parenchymal bacillary
       peliosis, fever with bacteremia, and cat-scratch disease, is associated
       with CNS diseases including cerebral and retinal bacillary angiomatosis,
       as well as cat-scratch-related encephalitis, myelitis, cerebral
       arteritis, and retinitis. We used a newly developed enzyme immunoassay
       and the polymerase chain reaction to investigate the association of R
       henselae infection with HIV-related CNS disease and found that whereas
       seroprevalence rates in HIV-positive patients unselected for neurologic
       disease were 4% to 5.5%, those with neurologic disease had
       seroprevalence rates of 32%. The ratio of organism-specific antibodies
       in CSF compared with serum suggested intra-blood-brain-barrier synthesis
       of these antibodies. CSF specimens containing only R henselae IgM had
       16S rDNA specific for R henselae. Stored serum from one of these
       patients indicated he had developed R henselae-reactive IgM antibodies
       10 months prior to the onset of neurologic disease. In the 14 patients
       for whom clinical data were available, evidence of CNS invasion by R
       henselae was accompanied by acute and subacute mental status changes
       including hallucinations, disorientation, and rapidly progressive
       dementia.
 DE    Adult  Antibodies/*ANALYSIS  AIDS-Associated
       Nephropathy/IMMUNOLOGY/*MICROBIOLOGY  Base Sequence  Case Report
       Comparative Study  Human  HIV Seropositivity/IMMUNOLOGY/MICROBIOLOGY
       Immunoenzyme Techniques  Male  Molecular Probes/GENETICS  Molecular
       Sequence Data  Polymerase Chain Reaction  Rickettsiaceae/*IMMUNOLOGY
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).